Jumonji Domain Containing Protein 4 (JMJD4)

JMJD4 is a novel putative histone demethylase that contains a jumonji domain.The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. While several JMJD proteins have been identified as being involved in chromatin regulation, histone demethylation and development, the JMJD4 has not been identified. JMJD4 is expressed in multiple tissues and At least three isoforms of JMJD4 are known to exist. This antibody will not recognize other members of the JMJD family.The gene contains 12 different introns. Transcription produces 13 different mRNAs, 11 alternatively spliced variants and 2 unspliced forms. There are 4 probable alternative promotors, 2 non overlapping alternative last exons and 2 validated alternative polyadenylation sites.