KRAB Domain Containing Protein 4 (KRBOX4)

ZNF673 has 2 splice variants, one encoding a deduced 98-amino acid protein, and the other encoding a deduced 166-amino acid protein. Both proteins have a 79-amino acid N-terminal KRAB domain. Lugtenberg et al. (2006) identified the ZNF673 gene within a 1-Mb region of chromosome X deleted in a patient with learning disabilities, retinal dystrophy, and short stature. They obtained the full-length ZNF673 sequence by PCR of a fetal brain cDNA library and 5-prime and 3-prime RACE. ZNF673 appeared to be a partial inverted duplication of the ZNF674 gene. The deduced ZNF673 protein contains KRAB A and B domains, but it lacks the C-terminal zinc finger domains found in ZNF674 due to the presence of numerous stop codons in all mRNAs analyzed. The ZNF673 and ZNF674 proteins share 80.7% identity until the first stop codon in ZNF673.