Kelch Like Protein 42 (KLHL42)
Английские синонимы
Ctb9; KLHDC5; Kelch Domain Containing Protein 5; Cullin-3-binding protein 9
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. E3 ubiquitin ligases are involved in targeting specific substrates for degradation by facilitating their ubiquitination.Overexpression of Ctb9/KLHDC5 resulted in an increase in microtubule density as well as persistent microtubule bridges between post-mitotic cells. Conversely, down-regulation of Ctb9/KLHDC5 showed a pronounced reduction in microtubule density. p60/katanin interacts with a complex consisting of Cul3 and Ctb9/KLHDC5, which results in ubiquitin laddering of p60/katanin. Also, Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
