Kinesin Family, Member 13A (KIF13A)

Kif13a, a plus end-directed microtubule-dependent motor protein that associates with beta-1 adaptin (AP1B1), a subunit of the AP1 adaptor complex.The 1,749-amino acid mouse Kif13a protein contains an N-terminal motor domain and an AF6/cno domain. The authors found that the cargo vesicles of Kif13a contain AP1 and mannose 6-phosphate receptor (M6PR). Overexpression of Kif13a resulted in mislocalization of AP1 and M6PR, and functional blockade of Kif13a reduced cell-surface expression of M6PR. Thus, the authors concluded that KIF13A transports M6PR-containing vesicles and targets M6PR from the trans-Golgi network to the plasma membrane via direct interaction with the AP1 adaptor complex.