Kinesin Family, Member 25 (KIF25)

KIF25 is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. The KNSL3 gene contains 9 exons and spans approximately 26 kb. A VNTR is present within intron 8. The mRNAs exhibited a complex tissue-specific expression pattern. The full-length KNSL3 transcript encodes a predicted 384-amino acid protein that shares 26 to 32% protein sequence identity with KINH (KIF5B), KINN, EG5 (KNSL1), KIF1A, and various mouse kinesins.