Kinesin Family, Member 5C (KIF5C)

By screening human brain cDNAs for the potential to encode proteins larger than 100 kD, Nagase et al. (1998) isolated a full-length KIF5C cDNA, which they called KIAA0531.The deduced 957-amino acid KIF5C protein shares 75.4% amino acid sequence identity with KIF5A across 953 amino acids. By SDS-PAGE, in vitro transcribed/translated KIF5C has an apparent molecular mass greater than 100 kD. RT-PCR detected KIF5C expression in several human tissues, with the highest expression in brain, prostate, and testis, and moderate expression in kidney, small intestine, and ovary. By radiation hybrid mapping, Nagase et al. (1998) mapped the KIF5C gene to chromosome 2.