LIM Domain Binding Protein 1 (LDB1)

CLIM1 and CLIM2 have a very high level of identity to each other and to the homologs in other species. CLIM2 encodes a 375-amino acid protein.human LMO2 interacted with human BEX2. Electrophoretic mobility shift assays showed that BEX2 and LMO2 were part of a DNA-binding complex that recognized the E-box element. Other components of this complex included NSCL2 (NHLH2) and LDB1.LDB1 associated with a complex containing LMO4, CTIP, and BRCA1 in transfected human embryonic kidney cells.LDB1 was consistently enriched in the superior temporal gyrus posterior temporal cortex, and perisylvian cortex. LDB1 may be involved in asymmetric patterning of the developing human cortex.