LIM Domains Containing Protein 2 (LIMD2)

LIMD2 belongs to the LIM only family of LIM proteins and was identified as one of biomarkers for papillary thyroid carcinoma lymph node metastasis from molecular profiling of matched samples. However, the biological function of LIMD2 remains unknown. To identify if the LIMD2 is biomarker for other cancers, highly specific LIMD2 polyclonal and monoclonal antibodies have been developed and several cancer cell lines were tested for LIMD2 expression. The cancer cell lines were derived from breast cancer, melanoma, bladder cancer, and thyroid cancer. The data show that the higher level of transcription and expression of LIMD2 are correlated with the more aggressive cancer cell lines. The migration assay indicated the higher level of expression of LIMD2 was also correlated with the higher degree of migration.