LLP Homolog (LLPH)

LLPH Belongs to the learning-associated protein family. This is a family of 121-amino acid secretory proteins consisting of learning associated protein 18 (LAPS18) and related sequences. LAPS18 functions in the regulation of neuronal cell adhesion and/or movement and synapse attachment. It has been shown to bind to the ApC/EBP (Aplysia CCAAT/enhancer binding protein) promoter and activate the transcription of ApC/EBP mRNA. A learning associated protein of slug with a molecular mass of 18 kDa (LAPS18) homologue from the expressed sequence tag database of Aplysia kurodai and named it Aplysia LAPS18-like protein (ApLLP). ApLLP encodes 120 amino acids and has 57% identity with LAPS18. In contrast to the previous findings, which showed that LAPS18 is secreted by COS-7 cells, ApLLP-EGFP was localized to the nucleus, and most of it to nucleoli.