LUC7 Like Protein 2 (LUC7L2)

The deduced full-length Luc7l2 protein contains 392 amino acids and has an N-terminal CCCH-type zinc finger, followed by a coiled-coil domain, a C2H2-type zinc finger, an arginine- and glutamine-rich (RE) region, an arginine- and serine-rich (RS) region, and a C-terminal arginine-rich (R) region. It also has 3 nuclear localization signals in the RS region. Northern blot analysis detected 2 major transcripts in mouse brain, kidney, heart, thymus, stomach, skeletal muscle, and testis. RT-PCR showed that all Luc7l2 variants were ubiquitously expressed in mouse tissues. EST database analysis suggested highest expression in lymph node, sympathetic ganglia, and midgestation embryos. Fluorescence-tagged Luc7l2 was expressed in a speckled nuclear pattern in transfected 293T cells.