Late Cornified Envelope Protein 1C (LCE1C)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE1C, which they called LEP3.Using real-time PCR, Jackson et al. (2005) detected high LCE1C expression in human fetal, arm, penal, and abdominal skin. Expression was much lower in vulva and was not detected in tongue and esophagus.Jackson et al. (2005) showed that expression of LCE1 genes, including LCE1C, was upregulated in cultured normal human keratinocytes by ultraviolet (UV) irradiation, but not by calcium. Induction of LCE1C could be detected 24 hours after UV irradiation and was very high 36 hours after UV irradiation.Jackson et al. (2005) determined that the LCE1C gene contains 2 exons. Exon 1 is noncoding.