Late Cornified Envelope Protein 1F (LCE1F)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE1F, which they called LEP6. RT-PCR showed that LEP6 was highly expressed in skin, with low levels in internal epithelia.Using real-time PCR, Jackson et al. (2005) detected LCE1F expression in human fetal, arm, penal, and abdominal skin, as well as in vulva and fibroblasts, but not in tongue or esophagus.Jackson et al. (2005) showed that expression of LCE1 genes, including LCE1F, was upregulated in normal human keratinocytes by ultraviolet irradiation, but not by calcium.Jackson et al. (2005) determined that the LCE1F gene contains 2 exons. Exon 1 is noncoding. The mouse Lce1f gene maps to a syntenic LCE gene cluster on chromosome 3F1.