Late Cornified Envelope Protein 2A (LCE2A)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE2A, which they called LEP9.Using real-time PCR, Jackson et al. (2005) detected LCE2A expression in human fetal, arm, penal, and abdominal skin. Much weaker expression was detected in vulva, but not in tongue or esophagus.Jackson et al. (2005) showed that expression of LCE2 genes, including LCE2A, was upregulated in cultured normal human keratinocytes by both ultraviolet irradiation and calcium.Jackson et al. (2005) determined that the LCE2A gene contains 2 exons. Exon 1 is noncoding.The mouse Lce2a gene maps to a syntenic LCE gene cluster on chromosome 3F1.