Late Cornified Envelope Protein 2C (LCE2C)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE2C, which they called LEP11. RT-PCR detected high LEP11 expression in skin and esophagus, but not in heart.Using real-time PCR, Jackson et al. (2005) detected low LCE2C expression in human fetal, arm, penal, and abdominal skin, and little to no expression in vulva, tongue, and esophagus.Jackson et al. (2005) showed that expression of LCE2 genes, including LCE2C, was upregulated in cultured normal human keratinocytes by both ultraviolet irradiation and calcium.Jackson et al. (2005) determined that the LCE2C gene contains 2 exons. Exon 1 is noncoding. The mouse Lce2c gene maps to a syntenic LCE gene cluster on chromosome 3F1.