Late Cornified Envelope Protein 3B (LCE3B)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE3B, which they called LEP14. RT-PCR detected strong LEP14 expression in human esophagus, but not in skin or heart.Using real-time PCR, Jackson et al. (2005) detected little to no LCE3B expression in human skin or internal epithelia.Jackson et al. (2005) determined that the LCE3B gene contains 2 exons. Exon 1 is noncoding.By genomic sequence analysis, Marshall et al. (2001) mapped the LCE3B gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) stated that the mouse Lce3b gene maps to a syntenic LCE gene cluster on chromosome 3F1.