Late Cornified Envelope Protein 3D (LCE3D)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE3D, which they called LEP16.Using real-time PCR, Jackson et al. (2005) detected very low LCE3D expression in adult and fetal skin. Low expression was also detected in internal epithelia, including vulva, tongue, and esophagus.Jackson et al. (2005) determined that LCE3D is a single-exon gene.By genomic sequence analysis, Marshall et al. (2001) mapped the LCE3D gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) determined that the LCE3D gene is located within intron 2 of the LCE3C gene and is oriented in the opposite direction. They stated that the mouse Lce3d gene maps to a syntenic LCE gene cluster on chromosome 3F1.