Late Cornified Envelope Protein 3E (LCE3E)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE3E, which they called LEP17. RT-PCR detected LEP17 in human skin, esophagus, and heart.Using real-time PCR, Jackson et al. (2005) detected very low LCE3E expression in adult and fetal skin. Low LCE3E expression was also detected in internal epithelia, including vulva, tongue, and esophagus.Jackson et al. (2005) showed that expression of LCE3E was upregulated in cultured normal human keratinocytes by ultraviolet radiation. At 48 hours after irradiation, the level of LCE3E was upregulated over 350-fold compared with mock-irradiated controls. LCE3E expression was not regulated by calcium.