Lengsin (LGSN)
Английские синонимы
GLULD1; LGS; Lens Glutamine Synthase-Like; Glutamate-Ammonia Ligase(Glutamine Synthetase)Domain Containing 1; Lens Protein With Glutamine Synthetase Domain
GLULD1 was among the most abundant cDNAs identified in adult lens, and EST database analysis showed that GLULD1 is among the most abundant noncrystallin mRNAs in human lens.GLULD1 homologs were restricted to vertebrate eye-bearing organisms. All orthologs contain a putative 14-3-3 protein-binding site, which is absent in GLUL.GLULD1 transcripts were identified in human lens, total eye, and whole embryo ESTs, indicating preferential expression in the lens. Western blot analysis detected a 57-kD band in extracts from transparent but not cataractous lens. Hydrophobic surface probe bis-ANS bound to 6 sites on lengsin, supporting a possible role as a chaperone; however, no anti-aggregating effect of lengsin was found.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
