Leucine Rich Repeat And Coiled Coil Domain Containing Protein 1 (LRRCC1)

LRRCC1 is required for the organization of the mitotic spindle. It maintains the structural integrity of centrosomes during mitosis.A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold. It is composed of repeating 20-30 amino acid stretches that are unusually rich in the hydrophobic amino acid leucine. Typically, each repeat unit has beta strand-turn-alpha helix structure, and the assembled domain, composed of many such repeats, has a horseshoe shape with an interior parallel beta sheet and an exterior array of helices. One face of the beta sheet and one side of the helix array are exposed to solvent and are therefore dominated by hydrophilic residues.