Leucine Rich Repeat And Fibronectin Type III Domain Containing Protein 3 (LRFN3)

The deduced 628-amino acid mouse protein contains a predicted signal peptide, a leucine-rich N-terminal domain, 6 leucine-rich repeat domains, a leucine-rich C-terminal domain, Ig C2-like domain (IgC2), a fibronectin type III domain, and a transmembrane region, but lacks a PDZ-binding motif found in LRFN1 LRFN2, and LRFN4. The LRFN family members share similarity with proteins of the Slit family , the Amigo family (AMIGO1), and the Nogo66 receptor (RTN4R).Northern blot analysis of adult mouse tissues detected Lrfn3 expression in brain, testis, small intestine, stomach, and kidney. In situ hybridization in mouse embryos demonstrated strong Lrfn3 expression in telencephalic and diencephalic vesicles at embryonic day (E) 11.5 to E17.5.