Leucine Rich Repeat And Ig Domain Containing Protein 3 (LINGO3)

The deduced 647-amino acid protein, which they designated LERN2, has an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, a C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail. It shares 53% amino acid identity with LRRN6A.LRRN6A was expressed in all central nervous system (CNS) regions examined, with highest levels in amygdala, hippocampus, thalamus, and cerebral cortex. In situ hybridization detected ubiquitous expression of Lrrn6a in mouse at embryonic day 7.5, but the expression was progressively restricted at later developmental stages. By postnatal day 7, Lrrn6a was expressed only in the CNS, primarily in the forebrain, in a pattern similar to that in adult mice.