Leucine Rich Repeat Containing Protein 10 (LRRC10)

The deduced 274-amino acid protein has a predicted molecular mass of 31.2 kD and contains 7 leucine-rich repeats of 20 to 23 amino acids and 2 possible C-terminal nuclear localization signals. Northern blot analysis detected a 1.3-kb mouse Lrrc10 transcript exclusively in heart.PCR analysis confirmed Lrrc10 expression in mouse heart with lower expression detected in skeletal muscle but not in any other tissues examined. In vitro transcription/translation of mouse Lrrc10 produced a peptide of approximately 35 kD. Confocal and fluorescence microscopy localized transfected Lrrc10 to the nucleus and mitochondria of COS-7 cells.