Lin-7 Homolog C (LIN7C)

The Mals proteins were predominantly expressed in both neuronal cell bodies and neuropil, and they were not detected in most nonneuronal cells in brain.The 3 proteins were Cask, a protein related to membrane-associated guanylate kinases (MAGUKs); Mint1 (APBA1), a putative vesicular trafficking protein; and the Velis. Cask, Mint1, and the Velis formed a tight, salt-resistant complex. the N-terminal domains of Cask, Mint1, and the Velis were involved in complex formation, leaving their C-terminal PDZ domains free to recruit adhesion molecules, receptors, and channels to the complex.Overexpression of LIN7C in OSCC cells resulted in a noninvasive phenotype with elevated beta-catenin (CTNNB1) expression. In immunodeficient mice, tumor cells expressing LIN7C showed reduced metastases.