Lines Homolog 1 (LINS1)

Using Drosophila Lin as a query to search human EST databases, followed by PCR of a mixed pool of human fetal brain, lung, liver, and kidney poly(A)+ RNAs, Katoh (2002) cloned LINS1, which the author called WINS1. The deduced 757-amino acid protein contains a Lin homologous domain and shares 60.0% amino acid identity with mouse Wins2. Northern blot analysis detected a 2.8 kb-transcript in adult testis, prostate, spleen, thymus, skeletal muscle, fetal kidney, and brain. LINS1 expression was not detected in any of 8 cancer cell lines tested.Katoh (2002) determined that the LINS1 gene contains 7 exons.By sequence analysis, Katoh (2002) mapped the LINS1 gene to chromosome 15q26.