Lipoma HMGIC Fusion Partner Like Protein 3 (LHFPL3)

LHFPL3 is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. A partial gene fragment named LHFPL4 corresponds to a portion of the first exon of this gene.By searching for sequences similar to LHFP, Petit et al. (1999) identified LHFPL3. The deduced partial protein shares 40% identity with the N-terminal part of LHFP.The International Radiation Hybrid Analysis Consortium mapped the LHFPL3 gene to chromosome 7 .