Maestro (MRO)

By sequencing a region of chromosome 18 that contains a segment deleted in the Ma29 lung cancer cell line, followed by screening a brain cDNA library, Yanaihara et al. (2001) cloned B29. B29 is located outside the Ma29 deletion. The deduced B29 protein contains 248 amino acids. Yanaihara et al. (2001) also identified 3 minor isoforms that differ in the reading frame utilized and in the presence or absence of exon 3 and/or exon 6. Expression levels were below the limit of detection for Northern blot analysis, but RT-PCR found near ubiquitous expression.Yanaihara et al. (2001) determined that the B29 gene contains 8 exons.By genomic sequence analysis, Yanaihara et al. (2001) mapped the B29 gene to chromosome 18q21.