Meiosis Arrest Female Protein 1 (MARF1)

Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Immunoscreening a HeLa cell cDNA expression library with a human autoimmune serum identified two clones that encode fragments of limkain b1 (LKAP). Mouse polyclonal antibodies raised against a bacterially expressed fragment of limkain b1 mark the same cytoplasmic structures as human serum, as does an EGFP:LKAPCT429 fusion protein expressed in HeLa cells.  limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity.