Membrane Protein, Palmitoylated 3 (MPP3)

MPP3 is a member of a family of membrane-associated proteins termed MAGUKs . MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. The putative MPP3 gene product has a molecular weight of 66 kD and is located on chromosome 17 in the same segment, 17q12-q21, as MPP2. The products of the MPP2 and MPP3 genes show 36% identity and 58% similarity to each other, and both show nearly 60% sequence similarity to the EMP55 gene which encodes an erythroid phosphoprotein that is a component of the red cell membrane.