Membrane Spanning 4 Domains Subfamily A, Member 8B (MS4A8B)

MS4A8B encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members.The predicted 250-amino acid protein is 63% identical to its mouse homolog. PCR analysis detected weak expression of MS4A8B in cDNA from 3 B-cell lines.By genomic sequence analysis, Liang and Tedder (2001) mapped the MS4A8B gene to chromosome 11q12-q13, in the same region as MS4A2 and MS4A3.