Misato Homolog 1 (MSTO1)

MSTO1, Belongs to the misato family.Present in all cell lines tested (at protein level). Widely expressed.Involved in the regulation of mitochondrial distribution and morphology.Tissue distribution of Misato exhibited ubiquitous distribution. Subcellular localization of the protein studied using anti-Misato antibody suggested that it is localized to the mitochondria. Further experiments of fractionating mitochondria revealed that Misato was localized to the outer membrane. The transfection of Misato siRNA led to growth deficiencies compared with control siRNA transfected HeLa cells, and the Misato-depleted HeLa cells showed apoptotic nuclear fragmentation resulting in cell death.