Mitochondrial Ribosomal Protein S15 (MRPS15)

MRPS15 encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q.The deduced 257-amino acid MRPS15 protein has a calculated molecular mass of 31.6 kD. Removal of a predicted 57-amino acid N-terminal mitochondrial localization signal results in a mature 23.5-kD protein. MRPS15 orthologs in mouse, Drosophila, C. elegans, yeast, and E. coli. Mouse and human MRPS15 share 62.9% amino acid identity.