Mitogen Activated Protein Kinase Kinase Kinase 10 (MAP3K10)

Mitogen-activated protein kinase kinase kinase 10 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.Additional cDNAs of the gene, which they called MST (MKN28-derived nonreceptor type of serine/threonine kinase), were isolated from a brain library. MST encodes a predicted 953-amino acid protein with a Src homology (SH3) domain, 2 leucine zipper domains, and a proline-rich domain. Northern blot analysis showed that the gene is moderately expressed in brain, skeletal muscle, and testis as a 3.8-kb mRNA.