Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15)

Mitogen Activated Protein Kinase Kinase Kinase 15 (MAP3K15) contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812, inhibited by phosphorylation at Ser-924 and Ser-994.Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4). MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).