Mitogen Activated Protein Kinase Kinase Kinase 9 (MAP3K9)

Mitogen-activated protein kinase kinase kinase 9 is an enzyme encoded by the MAP3K9 gene.While protein kinases vary widely in their primary structures, each contains a catalytic domain of 250 to 300 amino acids, which includes 11 highly conserved motifs or subdomains separated by sequences of amino acids with reduced conservation.The presence of these motifs within a newly characterized sequence is, therefore, strongly predictive of PK activity. Furthermore, specificity of a PK for phosphorylation of either tyr or ser/thr can be predicted by the sequence of 2 of the motifs (VIb and VIII) in which different residues are conserved in each class.