NANOG Neighbor Homeobox Protein (NANOGNB)

Contains 1 homeobox DNA-binding domain.Hox genes are a group of related genes that determine the basic structure and orientation of an organism.Hox genes are critical for the proper placement of segment structures of animals during early embryonic development. The products of Hox genes are known as Hox proteins. Hox proteins are transcription factors, as they are capable of binding to specific nucleotide sequences on the DNA called enhancers where they either activate or repress genes. The same Hox protein can act as a repressor at one gene and an activator at another. For example, in flies (Drosophila melanogaster) the protein product of the Hox gene Antennapedia activates genes that specify the structures of the 2nd thoracic segment, which contains a leg and a wing, and represses genes involved in eye and antenna formation.