NK2 Homeobox Protein 4 (NKX2-4)

Price et al. (1992) cloned mouse Nkx2d, which they called Nkx2.4. The Nkx2d protein contains a homeobox domain that is identical to that of mouse Ttf1. Wang et al. (2000) cloned a full-length cDNA encoding mouse Nkx2d. The deduced protein contains 355 amino acids. RNAse protection analysis of RNA from several mouse tissues detected expression of Nkx2d only in testis.Holland et al. (2007) stated that the NKX2-1 and NKX2-4 genes are collectively orthologous to Drosophila scro and comprise the Nk2.1 gene family.Using radiation hybrid analysis, Wang et al. (2000) mapped the NKX2D gene to chromosome 20p11, where it is linked with the NKX2B gene. By backcross analysis, they mapped the mouse Nkx2d gene to the distal region of chromosome 2.