NOP2/Sun Domain Family, Member 7 (NSUN7)

The nucleolus consists of a number of specific proteins that play a critical role in the assembly of ribosomes, as well as in the maintenance and structural integrity of the nucleolus. May have S-adenosyl-L-methionine-dependent methyl-transferase activity NSUN7 is a 718 amino acid protein that belongs to the methyltransferase superfamily. It is thought that NSUN7 is involved in mitochondrial rRNA processing in postmeiotic sperm and that disruption of the gene causes a general deficiency of mRNA translation and of the proteins required for optimal sperm function. Existing as three isoforms due to alternative splicing, NSUN7 may have Sadenosyl-L-methionine-dependent methyl-transferase activity.