Nescient Helix Loop Helix Protein 2 (NHLH2)

Brown et al. (1992) identified 2 structurally similar genes, denoted HEN1 (NHLH1) and HEN2 (NHLH2), the gene products of which are regulatory molecules that possess the DNA-binding and dimerization motif known as the basic helix-loop-helix (bHLH) domain. HEN1 and HEN2 are coexpressed in a human neuroblastoma cell line.Han et al. (2005) found that human  LMO2 interacted with human BEX2. Electrophoretic mobility shift assays showed that BEX2 and LMO2 were part of a DNA-binding complex that recognized the E-box element. Other components of this complex included NSCL2 and LDB1. LMO2 directly bound NSCL2 and upregulated NSCL2-dependent transcriptional activity, and BEX2 augmented this effect.