Nuclear Distribution Gene C Homolog (NUDC)

NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein.The deduced 331-amino acid protein contains a basic stretch from lys68 to arg76, an acidic region from asp144 to asp155, and a 94-amino acid C terminus that is highly homologous to A. nidulans NudC. Human NUDC shares 94% and 95% amino acid identity with mouse and rat NudC, respectively.Expression was primarily cytoplasmic, although punctate nuclear staining was also observed. In cultured human erythroid cells, NUDC mRNA and protein were highly expressed in rapidly proliferating cells and declined upon terminal differentiation.