Nuclear Distribution Protein NudE Homolog 1 (NDE1)

NDE1 encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Alternative splicing results in multiple transcript variants.The deduced 344-amino acid protein contains an asp- and glu-rich N-terminal half and a ser- and thr-rich C-terminal half. Rat Nude shares significant homology with a fungal nuclear distribution protein, NudE, and a Xenopus mitotic phosphoprotein, Mpp43. Northern blot analysis detected a 2.4-kb Nude transcript in all rat tissues examined.