Nuclear Factor I/A (NFIA)

Nuclear factor 1 A-type is a protein encoded by the NFIA gene.Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.Recognizes and binds the palindromic sequence 5"""-TTGGCNNNNNGCCAA-3""" present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.