Nuclear RNA Export Factor 2 (NXF2)

Nuclear RNA export factor 2 is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family.The deduced 626-amino acid NXF2 protein has the conserved domain structure of NXF1, including a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor-2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. Fluorescence microscopy demonstrated expression of NXF2 in the nucleoplasm and the nuclear envelope, but it was excluded from the nucleolus.