Nucleoporin 88kDa (NUP88)

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. NUP88 is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Fornerod et al. (1997) found that the NUP88 cDNA predicted a protein of 741 amino acids with a molecular mass of 85 kD. The protein migrated at 88 kD and was therefore named NUP88 to distinguish it from NUP85.