OTU Domain Containing Protein 6B (OTUD6B)

Deubiquitinating enzymes (DUBs) are capable of producing a free ubiquitin moiety from ubiquitin-fused precursors and ubiquitylated proteins in cells. DUBs possess conserved catalytic regions known as the """cys domain""" and the """his domain.""" There are 2 distinct families of DUBs: ubiquitin-specific processing proteases (UBPs, or USPs) and ubiquitin C-terminal hydrolases (UCHs). DUBA5 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Kayagaki et al. (2007) identified ovarian tumor domain (OTU)-containing protein 6B (OTUD6B) in a small interfering RNA (siRNA)-based screen for OTU deubiquitinating enzyme (DUB) family members. The 3,166-basepair mRNA contains an open reading frame (ORF) predicting a 293-amino acid protein.