OTU Domain Containing Protein 7A (OTUD7A)

Deubiquitinating enzymes (DUBs) are capable of producing a free ubiquitin moiety from ubiquitin-fused precursors and ubiquitylated proteins in cells. There are 2 distinct families of DUBs: ubiquitin-specific processing proteases (UBPs, or USPs) and ubiquitin C-terminal hydrolases (UCHs). OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.Kayagaki et al. (2007) identified ovarian tumor domain (OTU)-containing protein 7A (OTUD7A) in a small interfering RNA (siRNA)-based screen for OTU deubiquitinating enzyme (DUB) family members. The 3,042-basepair mRNA contains an open reading frame (ORF) predicting a 926-amino acid protein. In addition to an OTU domain, the protein contains an A20-like zinc finger (ZNF A20) domain at the carboxy terminus.