Outcome Predictor In Acute Leukemia 1 (OPAL1)

Holleman et al. (2006) stated that OPAL1 was identified in a microarray screen to identify possible markers of positive outcome in childhood acute lymphoblastic leukemia. The deduced protein contains a cytochrome c-like heme-binding site and a transmembrane domain.The International Radiation Hybrid Mapping Consortium mapped the C10ORF26 gene to chromosome 10. The MLL gene encodes a DNA-binding protein that methylates histone H3 lys4 (H3K4) and positively regulates expression of target genes, including multiple HOX genes. MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia, acute lymphoblastic leukemia, or mixed lineage (biphenotypic) leukemia.