P Antigen Family, Member 2 (PAGE2)

Many human tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. The MAGE (melanoma-specific antigen) and GAGE (G antigen) gene family members encode such antigens. Chen et al. (1998) manipulated the androgen-sensitive, nontumorigenic, prostate-specific antigen (PSA)-secreting cell line LNCaP in vivo to produce 3 cell sublines that were progressively more tumorigenic, metastatic, and androgen-insensitive.By searching an EST database for sequences similar to PAGE1, Brinkmann et al. (1998) identified PAGE2, which appeared to be expressed primarily in testis.Hartz (2008) mapped the PAGE2 gene to chromosome Xp11.21 based on an alignment of the PAGE2 sequence with the genomic sequence (build 36.1).