PDZ And LIM Domain Protein 3 (PDLIM3)

PDLIM3 contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle.This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene.Sequence analysis predicted that the 364-amino acid protein shares high homology with RIL and CLP36 (PDLIM1) and contains an N-terminal PDZ domain and a C-terminal LIM domain.