PDZ Domain Containing Protein 3 (PDZD3)

IKEPP is most closely related to PDZK1 and shares 77% sequence identity with the mouse type IIa sodium/inorganic phosphate cotransporter (SLC34A1)-associated protein. Northern blot analysis revealed expression of 2.3- and 2.5-kb IKEPP transcripts at high levels in kidney, with lower levels in intestine and colon and no expression in other tissues. mRNA Dot blot analysis of multiple gastrointestinal tissues detected IKEPP expression along the entire gastrointestinal tract, from the duodenum to the colon. Immunolocalization studies using colon carcinoma and adenocarcinoma cells showed that IKEPP preferentially accumulates in the subapical compartment and at the apical membrane.