POTE Ankyrin Domain Family, Member H (POTEH)

Bera et al. (2002) identified 10 paralogs of the POTE gene, including POTE22. By partially sequencing clones obtained from prostate and testis cDNA libraries, they determined that the POTE22 gene is transcribed.By PCR, Bera et al. (2004) cloned full-length POTE22 from normal prostate cDNA. The deduced 288-amino acid protein has a calculated molecular mass of 32.3 kD. POTE22 has 4 cysteine-rich N-terminal repeats, followed by 3 full and 1 partial ankyrin repeat. It lacks the C-terminal helical region found in several POTE paralogs. In vitro transcription and translation resulted in a protein of 34 kD.Bera et al. (2004) determined that the POTE22 gene has 12 exons and spans about 32 kb. Only the first 3 exons are coding exons.By genomic sequence analysis and FISH, Bera et al. (2002) mapped the POTE22 gene to chromosome 22q11.1.